Journal
MOLECULAR CELL
Volume 15, Issue 4, Pages 499-509Publisher
CELL PRESS
DOI: 10.1016/j.molcel.2004.07.009
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Funding
- NIDDK NIH HHS [1-P01-DK59820-01] Funding Source: Medline
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LRH-1 is an orphan nuclear receptor predominantly expressed in tissues of endodermal origin, where it controls development and cholesterol homeostasis. We show here that LRH-1 induces cell proliferation through the concomitant induction of cyclin D1 and Ell, an effect that is potentiated by its interaction with beta-catenin. Whereas beta-catenin coactivates LRH-1 on the cyclin El promoter, LRH-1 acts as a potent tissue-restricted coactivator of beta-catenin on the cyclin D1 promoter. The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the beta-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells.
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