Journal
TETRAHEDRON LETTERS
Volume 45, Issue 36, Pages 6795-6798Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.07.041
Keywords
cyclic peptides; disulfide bond; solid phase synthesis
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A novel approach for the synthesis of cyclic peptides that can exist in either linear or cyclized conformations is described. Synthesis of the peptides was achieved via a modified solid phase methodology. The reversible linear/cyclized (i.e., open/closed) states are controlled via the reduction/oxidation of a disulfide bond incorporated into the backbone of the peptide chain. (C) 2004 Elsevier Ltd. All rights reserved.
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