Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1664, Issue 2, Pages 182-188Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2004.05.007
Keywords
cationic amphipathic peptide; spider; scorpion; FITC-dextran; hemolysis; antimicrobial
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Pin2 and Oxki1 are cationic amphipathic peptides that permeate lipid membranes through formation of pores. Their mechanism of binding to phosphocholine (PC) membranes differs. Spin-probe experiments showed that both Pin2 and Oxki1 penetrate the lipid membrane of small unilamellar vesicles (SUVs). Moreover, the leakage of calcein and dextrans from PC vesicles showed that Pin2 agrees with the accumulation of peptides on lipid membranes and form pores of different size. On the other hand, Oxki1 did not act strictly cooperatively and form pores of limited size. (C) 2004 Elsevier B.V. All rights reserved.
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