Journal
IUBMB LIFE
Volume 56, Issue 9, Pages 529-534Publisher
WILEY
DOI: 10.1080/15216540400013861
Keywords
adenylyl cyclase; cAMP; bicarbonate; prokaryote; signal transduction
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Bicarbonate ion is fundamental to the biology of all living organisms. HCO3- is vital to such diverse physiological processes as carbon fixation, cellular homeostasis, sperm maturation, and nucleotide synthesis. A defined subset of adenylyl cyclases identified in eukaryotes and prokaryotes are directly activated by HCO3- . As such, cAMP represents the first identified biological effector for fluctuations in intracellular inorganic carbon levels. The identification of a signal transduction pathway activated by HCO3- has far reaching implications for understanding how the cell responds to fluctuations in this essential anion.
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