Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 92, Issue 3, Pages 1312-1319Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00140.2004
Keywords
-
Categories
Funding
- NCRR NIH HHS [P20 RR 16435] Funding Source: Medline
- NIDCD NIH HHS [DC 006070, DC 00566, DC 04657, R30 DC03912, DC 00244] Funding Source: Medline
Ask authors/readers for more resources
Some olfactory sensory neurons (OSNs) respond to odors with hyperpolarization. Although transduction for excitatory responses is mediated by opening of a cyclic nucleotide-gated (CNG) channel, there is controversy on the mechanism underlying inhibitory responses. We find that mouse OSNs respond to odorants by either depolarizing or hyperpolarizing responses in loose-patch measurements. In the perforated-patch configuration, OSNs not only responded with a current consistent with CNG channel-mediated excitation but also displayed enhancement of outward currents, consistent with inhibitory responses. Increasing cAMP levels pharmacologically elicited excitatory or inhibitory responses in different OSNs. In addition, OSNs from mice defective for the CNGA2 subunit of the CNG channel displayed neither excitatory nor inhibitory responses. Thus CNG channels mediate inhibitory olfactory responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available