Journal
APPLIED RADIATION AND ISOTOPES
Volume 88, Issue -, Pages 114-117Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2013.12.037
Keywords
Neutron Capture Therapy (NCT); Micro-Particle Induced X-ray Emission (Micro-PIXE); Fullerene; Metallofullerene; Gd@C-82; Biodistribution
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Funding
- Takasaki Ion Accelerators for Advanced Radiation Application (TIARA) of Japan Atomic Energy Agency (JAEA)
- JSPS KAKENHI [90241819, 23592084]
- Ministry of Health, LabourandWelfare
- Grants-in-Aid for Scientific Research [24659643, 23592084] Funding Source: KAKEN
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clarify the intra tumor distribution of gadlinium containing fullerene (Gd@C-82), micro particle induced X-ray emission (Micro-PIXE) analysis were performed. The tumor bearing BALB/c mice were injected Gd@C-82 and subcutaneous tumors were taken from 48 h after the intravenous injection. Using the Micro-PIXE method, we could visualize Gd intra tumor distribution. Therefore our results indicate the possibility that Micro-PIXE is useful technique for imaging the bioditribution of Gd, and Gd@C-82 is potentially useful Gd carrier for NCT. (C) 2014 Published by Elsevier Ltd.
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