Intra-tumor distribution of metallofullerene using micro-particle induced X-ray emission (PIXE)

clarify the intra tumor distribution of gadlinium containing fullerene (Gd@C-82), micro particle induced X-ray emission (Micro-PIXE) analysis were performed. The tumor bearing BALB/c mice were injected Gd@C-82 and subcutaneous tumors were taken from 48 h after the intravenous injection. Using the Micro-PIXE method, we could visualize Gd intra tumor distribution. Therefore our results indicate the possibility that Micro-PIXE is useful technique for imaging the bioditribution of Gd, and Gd@C-82 is potentially useful Gd carrier for NCT. (C) 2014 Published by Elsevier Ltd.