4.4 Article

Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a 10BSH-containing WOW emulsion

Journal

APPLIED RADIATION AND ISOTOPES
Volume 88, Issue -, Pages 32-37

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2014.01.014

Keywords

Boron neutron capture therapy; Hepatocellular carcinoma; Water-in-oil-in-water emulsion; Intra-arterial injection

Funding

  1. Ministry of Education, Science and Culture of Japan [18390360, 24390311]
  2. Kyushu Bureau of the Ministry of Economy, Trade and Industry of Japan [17G8009]
  3. Foundation of Kyushu Medical Resource in Japan
  4. Grants-in-Aid for Scientific Research [23300348, 24390311, 18390360] Funding Source: KAKEN

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A 63-year-old man with multiple HCC in his left liver lobe was enrolled as the first patient in a pilot study of boron neutron capture therapy (BNCT) involving the selective intra-arterial infusion of a (BSH)-B-10-containing water-in-oil-in-water emulsion ((BSH)-B-10-WOW). The size of the tumorous region remained stable during the 3 months after the BNCT. No adverse effects of the BNCT were observed. The present results show that (BSH)-B-10-WOW can be used as novel intra-arterial boron carriers during BNCT for HCC. (C) 2014 Elsevier Ltd. All rights reserved.

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