Journal
APPLIED RADIATION AND ISOTOPES
Volume 94, Issue -, Pages 113-117Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2014.07.015
Keywords
[F-18]SFB; PET; Microwave-assisted one-pot synthesis
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N-Succinimidyl-4-[F-18]fluorobenzoate ([F-18]SFB) is a potential prosthetic agent for novel tracer development in positron emission tomography (PET). Previously, we reported a microwave-assisted one-pot synthesis of [F-18]SFB with high efficacy. Herein, we reveal an improved and optimized approach based on this former model for producing [F-18]SFB. With optimized approaches, the entire protocol can be completed within 25 min, and [F-18]SFB is generated in satisfactory quality for direct use without further purification via high-performance liquid chromatography. (C) 2014 Elsevier Ltd. All rights reserved.
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