Journal
JOURNAL OF PHARMACOLOGICAL SCIENCES
Volume 96, Issue 1, Pages 15-18Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jphs.FMJ04002X3
Keywords
Na+/Ca2+ exchanger (NCX); stoichiometry; cardiac myocyte
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The stoichiometry of the Na+/Ca2+ exchanger (NCX) had been generally accepted as 3 Na+:1 Ca2+. However, recently a challenging stoichiometry of 4:1 was proposed. Therefore, using guinea pig ventricular cells, we re-examined the stoichiometry by measuring the reversal potential of the NCX current and intracellular Ca2+ concentrations under the whole-cell voltage clamp. We confirmed that the stoichiometry of NCX is 3:1 not 4:1. In addition, we explored the possible reasons for obtaining erroneous results of a 4:1 stoichiometry.
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