Journal
APPLIED RADIATION AND ISOTOPES
Volume 69, Issue 12, Pages 1796-1799Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2011.03.014
Keywords
Boron neutron capture therapy; Fractionated X-ray irradiation; Glioblastoma; Temozolomide; Phase II clinical study
Categories
Funding
- Ministry of Health, Labor and Welfare of Japan
- Japanese Ministry of Education, Science, and Culture [21890283, 20591728, 22791361]
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [21890283, 22791361, 20591728, 23390355, 23659596, 23592146] Funding Source: KAKEN
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Recently, we reported our clinical experiences of boron neutron capture therapy (BNCT) for the newly diagnosed glioblastoma. The major differences of our protocol from the other past studies were simultaneous use of both sodium borocapate and boronophenylalanine, and combination with fractionated X-ray irradiation. These results showed the efficacy of combination therapy with external beam X-ray irradiation and BNCT. For our future study, we planned the multi-centric phase II clinical study for newly diagnosed glioblastoma patients in Japan (OSAKA-TRIBRAIN0902, NCT00974987). (C) 2011 Elsevier Ltd. All rights reserved.
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