Journal
APPLIED RADIATION AND ISOTOPES
Volume 69, Issue 12, Pages 1807-1812Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2011.02.018
Keywords
Clinical trial; BPA uptake; Amino acid transport system; Proliferation marker
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Funding
- European Commission [QLK3-CT-1999-01067]
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The system L-amino acid transporter (LAT1) imports p-boronophenylalanine (BPA) mainly into proliferating cells. This study investigates in three tumor entities whether the proportion of tumor cells expressing LAT1 and/or Ki67 correlates with BPA uptake. Tumors were analyzed for (10)B concentration with prompt gamma-ray spectroscopy and for Ki67 and LAT1 expressions with immunohistochemical methods. The proportion of LAT1-expressing cells was much higher (5-90%) than that of Ki67-expressing cells (0-20%) and cells expressing both Ki67 and LAT1 (0-5%). Neither LAT1 nor Ki67 expression predicted BPA uptake. (C) 2011 Elsevier Ltd. All rights reserved.
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