Journal
APPLIED RADIATION AND ISOTOPES
Volume 69, Issue 4, Pages 663-669Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2011.01.006
Keywords
[Tc-99m(OH2)(3)(CO)(3)](+) precursor; Technetium; Radiolabeling; Experimental design; Dextran; Statistical analysis
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Funding
- National Commission for Nuclear Energy (CNEN, Sao Paulo, Brazil)
- National Counsel of Technological and Scientific Development (CNPq, Brasilia, Brazil)
- International Atomic Energy Agency (IAEA, Vienna, Austria)
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The objective of this study was the development of a statistical approach for radiolabeling optimization of cysteine-dextran conjugates with Tc-99m tricarbonyl core. This strategy has been applied to the labeling of 2-propylene-S-cysteine-dextran in the attempt to prepare a new class of tracers for sentinel lymph node detection, and can be extended to other radiopharmaceuticals for different targets. The statistical routine was based on three-level factorial design. Best labeling conditions were achieved. The specific activity reached was 5 MBq/mu g. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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