Journal
APPLIED RADIATION AND ISOTOPES
Volume 69, Issue 7, Pages 1014-1018Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2011.03.041
Keywords
Radiosynthesis; [F-18]FPy-DUPA-Pep; PSMA targeting ligand
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Funding
- DAAD-HEC (Deutscher Akademischer Austausch Dienst-Higher Education Commission, Pakistan [425, A/06/19221]
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Due to the specificity of expression of PSMA (prostate specific membrane antigen) particularly in prostate cancer cells (e.g. LNCaP), numerous PSMA ligands have been synthesized until now. In the current study, we synthesized DUPA-Pep having 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) linked via 8-aminooctanoic acid to two phenylalanine residues and chose 6-[F-18]fluoronicotinic acid 2,3,5,6-tetrafluorophenyl ester [F-18]FPy-TFP as a prosthetic group for coupling. [F-18]FPy-DUPA-Pep was obtained in a radiochemical yield of 48 +/- 0.9% (decay uncorrected) within 50 min with a chemical purity of > 98%. (C) 2011 Elsevier Ltd. All rights reserved.
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