Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 92, Issue 3, Pages 1615-1624Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00848.2003
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Funding
- NIDA NIH HHS [DA 16454] Funding Source: Medline
- NIMH NIH HHS [MH 60450, MH 60013, MH 61492] Funding Source: Medline
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Computational modeling demonstrates that encoding and context-dependent retrieval of memories in regionCA1 of the hippocampus will be most effective when the phase of strongest entorhinal input ( to stratum lacunosum-moleculare) is offset from the phase of maximal induction of long-term potentiation at Schaffer collateral synapses ( in s. radiatum). This would allow entorhinal input to play a role in both retrieval and encoding without engaging long-term potentiation (LTP) during retrieval. Experiments in brain slice preparations of the hippocampal formation tested the relationship between rhythmic input to s. lacunosum-moleculare and the time of maximal LTP induction at Schaffer collateral synapses in s. radiatum. Analysis of the data demonstrates a statistically significant difference in the induction of LTP for different time intervals between the end of each four-pulse train in s. lacunosum-moleculare and the single pulse s. radiatum stimulation. The time of maximal LTP induction was found to be similar to30 ms after the end of lacunosum-moleculare stimulation, consistent with the requirements of the model.
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