Journal
APPLIED RADIATION AND ISOTOPES
Volume 68, Issue 2, Pages 325-328Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2009.11.002
Keywords
Carbon-11; Fasudil; Hydroxyfasudil; Rho-kinases; Intracellular labeling
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Funding
- Heart and Stroke Foundation Molecular Function and Imaging [6242]
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N-[C-11]-methyl-hydroxyfasudil was synthesized as a new potential radiotracer for rho-kinases (ROCKS) via a two-step one-pot radiosynthesis. The first step was the methylation of the precursor N-Boc-hydroxyfasudil-sodium salt/benzo-15-crown-5 complex with [C-11]methyl iodide. The second step involved deprotection of the tert-butoxycarbonyl protecting group. The radiochemical and chemical purities of N-[C-11]-methyl-hydroxyfasudil were >95% and specific radioactivity was 1565-2565 mCi/mu mol at the end of the synthesis. (C) 2009 Elsevier Ltd. All rights reserved.
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