Journal
PLANT FOODS FOR HUMAN NUTRITION
Volume 59, Issue 4, Pages 143-147Publisher
SPRINGER
DOI: 10.1007/s11130-004-0025-2
Keywords
erythrocytes; fenugreek seed polyphenols; hemolysis; hydrogen peroxide; lipid peroxidation
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A polyphenol-rich extract from the seeds of fenugreek was evaluated for its protective effect against hydrogen peroxide(H2O2)induced oxidation in normal and diabetic human erythrocytes (RBCs). RBCs, preincubated with increasing amounts of fenugreek seed extract and challenged with H2O2, were analyzed for hemolysis and lipid peroxidation. RBCs from diabetic subjects were more susceptible to oxidative hemolysis and lipid peroxidation than those from normal subjects. However preincubation with the polyphenol-rich extract significantly reduced the oxidative modifications in both the groups. The inhibition of lipid peroxidation was concentration-dependent up to 100 mul of extract, which contained 0.75mM gallic acid equivalent (GAE) of phenolic compounds. These findings demonstrate the potent antioxidant properties of the fenugreek seeds.
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