Journal
BEHAVIOURAL PHARMACOLOGY
Volume 15, Issue 5-6, Pages 327-339Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00008877-200409000-00004
Keywords
environment; novelty; context; addiction; learning; stress; sensitization; psychostimulants; opioids; immediate early genes; dendrites; dendritic spines; plasticity
Funding
- NIDA NIH HHS [K05 DA00473, R37 DA04294] Funding Source: Medline
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Repeated administrations of addictive drugs produce long-lasting changes in brain and behavior. However, drug-induced neurobehavioral plasticity is not a mere function of the neuropharmacological actions of drugs, but the result of complex drug-environment interactions. In the present review we summarize results obtained in a series of studies using an animal model of drug-environment interaction, showing that environmental context and past drug history interact to modulate the effects of amphetamine, cocaine and morphine on behavior, gene expression and structural plasticity. These findings may help shed some light on the conditions necessary for addictive drugs to enduringly alter brain and behavior. (C) 2004 Lippincott Williams Wilkins.
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