Journal
APPLIED RADIATION AND ISOTOPES
Volume 68, Issue 2, Pages 293-296Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2009.10.005
Keywords
Electrophylic fluorination; F-18-labeling; Catalysis; EF5
Categories
Funding
- NIH [CA87645]
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Catalysis for reaction of electrophilic fluorine addition to a fluorinated double bond is described. The presence of small amounts of iodine, bromine, or boron trifluoride increases an overall product yield and degree of fluorine incorporation, making the reaction a more efficient method for preparation of F-18 positron emission tomography agents. A possible mechanism of catalytic action of iodine is discussed. (C) 2009 Elsevier Ltd. All rights reserved.
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