Journal
GENETIC EPIDEMIOLOGY
Volume 27, Issue 2, Pages 162-172Publisher
WILEY
DOI: 10.1002/gepi.20013
Keywords
DNA microarrays; genetics; human autoimmune disease; gene order
Funding
- NCI NIH HHS [CA90949] Funding Source: Medline
- NHLBI NIH HHS [HL68744] Funding Source: Medline
- NIAID NIH HHS [AI44924] Funding Source: Medline
- NIAMS NIH HHS [AR41943] Funding Source: Medline
- NIDDK NIH HHS [DK58749, DK58765] Funding Source: Medline
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Autoimmune diseases arise from complex interactions between environmental and genetic factors. Genetic linkage scans show that different autoimmune diseases share overlapping susceptibility loci. Lymphocytes from individuals with different autoimmune diseases, as well as unaffected first-degree relatives, also share a common gene expression profile. We sought to determine if genes within this autoimmune expression profile were nonrandomly distributed in the genome and if their distribution overlapped with shared disease susceptibility loci. We found that differentially expressed genes were distributed in a nonrandom fashion in chromosomal domains within the genome. Furthermore, positions of these domains were not statistically different from a number of shared autoimmune disease susceptibility loci. To our knowledge, this is the first study showing concordance between gene expression and genetic linkage results in common complex multifactorial human diseases. (C) 2004 Wiley-Liss, Inc.
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