Journal
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
Volume 51, Issue 3, Pages 407-410Publisher
MOSBY, INC
DOI: 10.1016/j.jaad.2004.01.044
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Topical treatment of cutaneous lupus erythematosus usually includes potent glucocorticosteroids. However, prolonged use causes adverse side effects including skin atrophy as the foremost concern. In contrast to glucocorticosteroids, the anti-inflammatory and immunosuppressive macrolactam pimecrolimus has no atrophogenic potential. Affected areas of 11 patients with different forms of lupus erythematosus were treated with pimecrolimus 1% cream tinder semiocclusive conditions twice daily for 3 weeks. Skin involvement before and after therapy was assessed by means of a clinical score. in all patients, significant regression of skin lesions was observed after therapy (P<.001). This was an open and uncontrolled study on a limited number of cases. We suggest that pimecrolimus 1% cream Could be an efficacious and safe treatment option for cutaneous lupus erythematosus.
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