Journal
APPLIED RADIATION AND ISOTOPES
Volume 67, Issue 4, Pages 581-589Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2008.08.018
Keywords
Apparatus; [C-11]acetate; [C-11]choline; [C-11]methionine; [C-11]PIB
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Funding
- Hong Kong Sanatorium Hospital
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A simple, efficient and remotely operated synthesis apparatus for carrying out routine [C-11]carboxylation, on-column and bubbling [C-11]methylation was essential for reliable, day-to-day production of [C-11]-labelled PET radiopharmaceuticals. We developed an in-house apparatus specifically applied to the synthesis of [C-11]acetate, [C-11]choline, [C-11]methionine and 2-(4'-N-[C-11]methylaminophenyl)6-hydroxybenzothiazole ([C-11]PIB), where high radiochemical purity (>= 97%) and moderate radiochemical yields (18% for [C-11]PIB, 41-55% for the others) could be achieved. These findings provided evidence that this was a fast, versatile and reliable apparatus suitable for a PET/CT centre with limited financial budget and hot cell space for synthesis of [C-11]-labelled radiopharmaceuticals. (C) 2008 Elsevier Ltd. All rights reserved.
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