Journal
BIOLOGICAL PSYCHIATRY
Volume 56, Issue 5, Pages 376-378Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2004.06.017
Keywords
association study; bipolar disorder; brain-derived neurotrophic factor; genetics; single nucleotide polymorphism; susceptibility
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Background: Two previous studies reported a significant association between a missense polymorphism (Val66Met) in the brain-derived neurotrophic factor (BDNF) gene and bipolar disorder; however, contradictory negative results have also been reported necessitating further investigation. Methods: We organized a multicenter study of a relatively large sample of 519 patients with bipolar disorders (according to DSM-IV criteria) and 588 control subjects matched for gender, age, and ethnicity (Japanese). Genotyping was done by polymerase chain reaction-based restriction fragment length polymorphism or direct sequencing. Results: The genotype distributions and allele frequencies were similar among the patients and control subjects. Even if the possible relationships of the polymorphism with several clinical variables (i.e., bipolar I or II, presence of psychotic features, family history, and age of onset) were examined, no variable was related to the polymorphism. Conclusions: The Val66Met polymorphism of the BDNF gene is unrelated to the development or clinical features of bipolar disorder, at least in a Japanese population.
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