Journal
FREE RADICAL RESEARCH
Volume 38, Issue 9, Pages 1021-1026Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10715760410001717327
Keywords
yeast; Saccharomyces cerevisiae; superoxide dismutase; free radicals; oxidative stress; aging
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Yeast (Saccharomyces cerevisiae) mutants lacking CuZn-superoxide dismutase (CuZnSOD) are hypersensitive to oxygen and have significantly decreased replicative life span. Both these defects can be ameliorated by exogenous ascorbate. The effect of ascorbate on life span is complicated by auto-oxidation of its compound in the medium. If negative effects of auto-oxidation are prevented by exchange of the medium, ascorbate prolongs not only mean but also maximal replicative life span of the yeast in the atmosphere of air and of pure oxygen. These results demonstrate that life span shortening due to the lack of a vital antioxidant enzyme can be ameliorated by a low-molecular weight antioxidant.
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