Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 12, Issue 17, Pages 4557-4564Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.07.019
Keywords
oxazolidinone; 4.5.6,7-tetrahydro-thieno[3,2-c]pyridine; linezolid; in vitro activity
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Synthesis of a number of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine substituted oxazolidinones have been reported. They have been screened against a panel of Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. A SAR has been developed. Compound 15 showed comparable activity (MIC) to linezolid and superior to eperezolid. (C) 2004 Elsevier Ltd. All rights reserved.
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