Journal
NATURE IMMUNOLOGY
Volume 5, Issue 9, Pages 891-898Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1104
Keywords
-
Categories
Funding
- NCI NIH HHS [5T32 CA009056] Funding Source: Medline
- NIGMS NIH HHS [GM07185] Funding Source: Medline
Ask authors/readers for more resources
Interferon (IFN) activates the signal transducer and activator of transcription (STAT) pathway to regulate immune responses. The protein inhibitor of activated STAT (PIAS) family has been suggested to negatively regulate STAT signaling. To understand the physiological function of PIAS1, we generated Pias1(-/-) mice. Using PIAS1-deficient cells, we show that PIAS1 selectively regulates a subset of IFN-gamma- or IFN-beta-inducible genes by interfering with the recruitment of STAT1 to the gene promoter. The antiviral activity of IFN-gamma or IFN-beta was consistently enhanced by Pias1 disruption. Pias1(-/-) mice showed increased protection against pathogenic infection. Our data indicate that PIAS1 is a physiologically important negative regulator of STAT1 and CL m suggest that PIAS1 is critical for the IFN-gamma- or IFN-beta-mediated innate immune responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available