Journal
PEPTIDES
Volume 25, Issue 9, Pages 1389-1403Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2003.11.026
Keywords
peptide signaling; Staphylococcus aureus; Gram-positive bacteria; histidine kinase
Funding
- NIGMS NIH HHS [GM07739] Funding Source: Medline
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There are two basic types of bacterial communication systems-those in which the signal is directed solely at other organisms and those in which the signal is sensed by the producing organism as well. The former are involved primarily in conjugation; the latter in adaptation to the environment. Gram-positive bacteria use small peptides for both types of signaling, whereas Gram-negative bacteria use homoserine lactones. Since adaptation signals are autoinducers the response is population-density-dependent and has been referred to as quorum-sensing. Gram-negative bacteria internalize the signals which act upon an intracellular receptor, whereas Gram-positive bacteria use them as ligands for the extracellular receptor of a two-component signaling module. In both cases, the signal activates a complex adaptation response involving many genes. (C) 2004 Elsevier Inc. All rights reserved.
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