Journal
PEPTIDES
Volume 25, Issue 9, Pages 1465-1476Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2003.10.022
Keywords
yeast mating pheromone; mitogen-activated protein kinase; signal transduction; Saccharomyces cerevisiae
Funding
- NIGMS NIH HHS [GM60366, GM69013, R01 GM060366-04, R01 GM060366] Funding Source: Medline
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The intracellular signal transduction pathway by which the yeast Saccharomyces cerevisiae responds to the presence of peptide mating pheromone in its surroundings is one of the best understood signaling pathways in eukaryotes, yet continues to generate new surprises and insights. In this review, we take a brief walk down the pathway, focusing on how the signal is transmitted from the cell-surface receptor-coupled G protein, via a MAP kinase cascade, to the nucleus. (C) 2004 Elsevier Inc. All rights reserved.
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