Journal
CANCER BIOLOGY & THERAPY
Volume 3, Issue 9, Pages 819-824Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cbt.3.9.1101
Keywords
cancer; chemotherapy; chromatin remodeling; MDR1; multidrug resistance
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The development of multidrug resistance (MDR) in cancer can severely impede the efficacy of chemotherapy treatment. P-glycoprotein (Pgp) overexpression, encoded by the MDR1 gene, is a well-established mediator of MDR. MDR1 expression is rapidly uprequlated by chemotherapeutic drugs and a number of other exogenous stimuli, however the mechanisms underlying its transcriptional regulation remain unclear. In recent years, research has indicated that chromatin accessibility, or epigenetic modifications, will play a large role in controlling the endogenous MDR1 expression state, and its response to activation stimuli. This review examines some of these studies, and discusses how new developments from the greatly expanding epigenetics field may extend to MDR1 transcriptional research.
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