Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 6, Issue 5, Pages 776-782Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc049953+
Keywords
-
Ask authors/readers for more resources
It has been demonstrated previously by us that guanide-containing compounds (1 and 2) can inhibit significantly dihydrofolate reductase (DHFR). In this report, we have produced an array of alkyl- and aryl-based biguanide compounds using microwave irradiation. Further, we have demonstrated the use of TMSCl for the first time as an excellent and practical catalyst for the formation of alkyl and aryl biguanides. Using these methods, we prepared a 60-compound collection, of which one compound (21g) showed approximately one-half of the inhibitory activity of the parent compound 2.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available