Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 9, Issue 5, Pages 978-981Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.1783897
Keywords
airway injury; diagnostic; laser; malignant; oral cancer
Funding
- NCRR NIH HHS [RR-01192] Funding Source: Medline
- NIBIB NIH HHS [EB-00293] Funding Source: Medline
- PHS HHS [91717] Funding Source: Medline
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Optical coherence tomography (OCT)/optical Doppler tomography (ODT) provides real-time in vivo high-resolution (10-mum) imaging of tissues and real-time spatially resolved blood flow in microvasculature. Hamster cheek pouches with induced dysplasia and malignancies were imaged with OCT/ODT to assess the potential for application to airway malignancy. In 22 Golden Syrian hamsters, 0.5% 9,11 0-dimethyl-1,2-benzanthracene induces carcinogenesis over 10 weeks in right side cheek pouches; the left side three served as controls. The cheek pouches are imaged in vivo prior to sacrifice, and in vitro after excision, using a prototype 1310-nm broadband superluminescent diode based OCT/ODT device. Images are compared to standard histopathology. OCT imaging offers good resolution of the hamster cheek pouches to depths of 1 to 3 mm and paralleled histologic images. The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis. (C) 2004 Society of Photo-Optical Instrumentation Engineers.
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