Journal
DEVELOPMENTAL CELL
Volume 7, Issue 3, Pages 291-299Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2004.08.007
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Funding
- NIDCR NIH HHS [DE13223] Funding Source: Medline
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In this review, we outline the gene-regulatory interactions driving neural crest development and compare these to a hypothetical network operating in the embryonic ectoderm of the cephalochordate amphioxus. While the early stages of ectodermal patterning appear conserved between amphioxus and vertebrates, later activation of neural crest-specific factors at the neural plate border appears to be a vertebrate novelty. This difference may reflect co-option of genetic pathways which conferred novel properties upon the evolving vertebrate neural plate border, potentiating the evolution of definitive neural crest.
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