Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 4, Issue 9, Pages 1201-1207Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2004.05.011
Keywords
macrolides; Fas; FasL; lymphocytes; Bcl-xL; apoptosis
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To evaluate the anti-inflammatory action of macrolide antibiotics, we examined whether macrolide antibiotics could induce apoptosis of activated lymphocytes. The proportion of apoptotic cells was augmented by clarithromycin (CLR) and azithromycin (AZM) compared with control. There was no significant difference in Fas and Fas-ligand expression between the control and macrolide-treated groups. CLR and AZM inhibited the expression of Bcl-xL compared with that of control. Our results suggest that CLR and AZM enhance apoptosis of activated lymphocytes by down-regulation of Bcl-xL. (C) 2004 Elsevier B.V. All rights reserved.
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