Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 12, Issue 17, Pages 4585-4600Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.07.010
Keywords
non-thiol farnesyltransferase inhibitors; structure-activity relationships
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We have designed arylfurylacryl-substituted benzophenones as non-thiol farnesyltransferase inhibitors utilizing a novel aryl binding site of farnesyltransferase. These compounds display activity in the low nanomolar range. (C) 2004 Elsevier Ltd. All rights reserved.
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