Journal
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
Volume 33, Issue 5, Pages 1042-1049Publisher
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/H08-068
Keywords
heat shock proteins; Hsp70; Hsp27; NF-kappa B; hypertension; angiotensin II
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Heat shock proteins (HSPs) are critical for cell survival and have several mechanisms of action. HSPs regulate protein folding, suppress apoptosis, and regulate anti-oxidative activity. In addition, HSPs are involved in the regulation of the pro-inflammatory transcription factor nuclear factor (NF)-kappa B. When angiotensin (Ang) II is infused into rats, there is a significant increase in systolic blood pressure, and NF-kappa B is activated in the heart. If rats are heat shocked to induce the heat shock response and HSPs before Ang II infusion, there is a significant suppression of both the Ang II-induced increase in blood pressure and NF-kappa B activation in the heart. Although the role of specific HSPs in the regulation of NF-kappa B is unclear, several HSPs, including Hsp27 and Hsp70, are thought to be involved in the regulation of Ang II-induced NF-kappa B. The role of Hsp27 and Hsp70 in NF-kappa B activation is reviewed here, along with evidence suggesting that HSPs regulate Ang II-induced blood pressure through the regulation of NF-kappa B.
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