Journal
NATURE MEDICINE
Volume 10, Issue 9, Pages 917-919Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nm1095
Keywords
-
Ask authors/readers for more resources
Several non-hypercalcemic analogs of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)(2)D-3 analog, in xenografted mice. In human colon cancers, elevated SNAIL expression correlates with downregulation of VDR.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available