Journal
MITOCHONDRION
Volume 4, Issue 5-6, Pages 695-703Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.mito.2004.07.020
Keywords
mitochondria; photoreceptors; cristae junction; apoptosis; calcium; lead
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Our previous work suggests that cone photoreceptor inner segment (CIS) mitochondria demand and produce more ATP than rods. The CISs utilize two complimentary strategies to increase ATP production: increase the absolute number of mitochondria and their cristae surface membrane area. In this treatise, we ask: How are crista junctions formed and regulated? Once formed, are there physical mechanisms that constrain their diameter? How are the constrictions in cristae regulated and is this key for cytochrome c release during apoptosis? What are their differences in rod and cone susceptibility to apoptotic cell death during calcium overload and oxidative stress? (C) 2004 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
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