Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 9, Issue 3, Pages 264-270Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1472-6483(10)62140-2
Keywords
apoptosis; corpus luteum; nitric oxide; progesterone; rabbit
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Funding
- NICHD NIH HHS [HD-19430] Funding Source: Medline
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To determine if nitric oxide (NO) plays a role in corpus luteum (CL) physiology by affecting progesterone secretion or luteal apoptosis, an in-vitro pseudopregnant rabbit ovarian perfusion system was used to measure the effects of an inhibitor of NO synthesis, N-G-nitro-L-arginine methyl ester (L-NAME), on progesterone secretion and corpus luteal apoptosis as measured by internucleosomal DNA breakdown. Pseudopregnant rabbit ovaries perfused in vitro with L-NAME did not demonstrate any significant differences compared with control ovaries in progesterone secretion. However, apoptosis, as measured by internucleosomal breakdown, was significantly increased in L-NAME-perfused CL compared with controls. While NO does not appear to directly affect progesterone secretion, there does appear to be a role for NO in CL maintenance, or a role for inhibition of NO production in CL regression.
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