Journal
APPLIED PHYSICS LETTERS
Volume 104, Issue 3, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4862461
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Funding
- NIH [RO1EB016034, R01CA170734, T32CA138312]
- NSF [0645080]
- Life Sciences Discovery Fund [3292512]
- Department of Bioengineering at the University of Washington
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0645080] Funding Source: National Science Foundation
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A composite contrast agent, a nanoemulsion bead with assembled gold nanospheres at the interface, is proposed to improve the specific contrast of photoacoustic molecular imaging. A phase transition in the bead's core is induced by absorption of a nanosecond laser pulse with a fairly low laser fluence (similar to 3.5 mJ/cm(2)), creating a transient microbubble through dramatically enhanced thermal expansion. This generates nonlinear photoacoustic signals with more than 10 times larger amplitude compared to that of a linear agent with the same optical absorption. By applying a differential scheme similar to ultrasound pulse inversion, more than 40 dB contrast enhancement is demonstrated with suppression of background signals. (C) 2014 AIP Publishing LLC.
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