Journal
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
Volume 68, Issue 3, Pages 453-+Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MMBR.68.3.453-473.2004
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Funding
- NIGMS NIH HHS [R01 GM053228, GM53228] Funding Source: Medline
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Carbon monoxide (CO) has long been known to have dramatic physiological effects on organisms ranging from bacteria to humans, but recently there have a number of suggestions that organisms might have specific sensors for CO. This article reviews the current evidence for a variety of proteins with demonstrated or potential CO-sensing ability. Particular emphasis is placed on the molecular description of CooA, a heme-containing CO sensor from Rhodospirillum rubrum, since its biological role as a CO sensor is clear and we have substantial insight into the basis of its sensing ability.
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