Journal
JOURNAL OF VIROLOGY
Volume 78, Issue 17, Pages 9573-9578Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.17.9573-9578.2004
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Funding
- NIAID NIH HHS [R01 AI47770, R21 AI052051, R01 AI052051, R01 AI047770] Funding Source: Medline
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The sequence of events leading to human immunodeficiency virus fusion and entry likely involves the recruitment of multiple receptor and coreceptor proteins to a specific complex by the viral envelope. Using fluorescence recovery after photobleaching technology, we find that both CD4 and CCR5 are mobile in the cell membrane. Interestingly, our findings also suggest that the seven-span transmembrane coreceptor is significantly more mobile than CD4 and requires membrane cholesterol for mobility.
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