Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 190, Issue 5, Pages 985-988Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/423285
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To clarify the pathogenesis of chronic active Epstein-Barr virus (EBV) infection, EBV-specific CD8(+) T cells were enumerated, by use of human leukocyte antigen (HLA)-A*2402-restricted tetramers, in 8 patients with chronic active EBV infection, 10 patients with infectious mononucleosis, and 16 EBV-seropositive healthy control subjects. In most of the patients with chronic active EBV infection, EBV-specific CD8(+) T cells were not detected. Of note, latent membrane protein 2 specific CD8(+) T cells were not detectable in any patients with chronic active EBV infection. In contrast, EBV-specific CD8(+) T cells were detected in patients with infectious mononucleosis and in healthy control subjects. Low frequencies of EBV-specific CD8(+) T cells may be one of the immunological features of chronic active EBV infection.
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