Journal
APPLIED PHYSICS LETTERS
Volume 104, Issue 8, Pages -Publisher
AMER INST PHYSICS
DOI: 10.1063/1.4866460
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- Lendulet Program of the Hungarian Academy of Sciences
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We report the assessment of the sensitivity of a microplate-compatible resonant waveguide grating imager. The sensitivity to bulk refractive index changes was determined using a serial dilution of glycerol solution with the help of a refractometer. The surface sensitivity was examined using layer-by-layer polyelectrolyte films in conjunction with optical waveguide lightmode spectroscopy and characterized by the binding of acetazolamide to immobilized carbonic anhydrase under microfluidics. The results suggest that the imager has a limit of detection down to 2.2 x 10(-6) for refractive index change and 0.078 ng/cm(2) for the adsorbed mass. (C) 2014 AIP Publishing LLC.
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