Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 3, Issue 9, Pages 801-808Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd1500
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Drug discovery is extremely difficult. There are many unanticipated scientific, medical and business challenges to every drug discovery programme. It is important to increase our understanding of the fundamental properties of effective drugs so that we can anticipate potential problems in developing new agents. This article addresses potential drug discovery and development risks associated with the biochemical mechanism of drug action, and proposes simple rules to minimize these risks.
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