Journal
DEVELOPMENTAL DYNAMICS
Volume 231, Issue 1, Pages 199-203Publisher
WILEY-BLACKWELL
DOI: 10.1002/dvdy.20106
Keywords
Cre recombinase; transgenic mice; hair cells
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Funding
- NCI NIH HHS [CA21765] Funding Source: Medline
- NEI NIH HHS [EY12950] Funding Source: Medline
- NIDCD NIH HHS [DC05168, DC00215, DC06471, DC04761] Funding Source: Medline
- NIMH NIH HHS [MH61971] Funding Source: Medline
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We made a transgenic mouse that expresses Cre recombinase activity in inner ear hair cells by using a modified bacterial artificial chromosome containing Prestin. Cre recombinase activity was restricted to inner and outer hair cells, a subset of vestibular hair cells, spiral and vestibular ganglia in the inner ear, and a subset of cells in the testis, epididymis, and ear bone. This mouse will be useful for hair-cell-specific gene targeting. (C) 2004 Wiley-Liss, Inc.
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