Journal
BIOPOLYMERS
Volume 75, Issue 1, Pages 32-45Publisher
WILEY
DOI: 10.1002/bip.20109
Keywords
electronic CD; peptide 3(10)-helix; Raman optical activity; C-alpha-tetrasubstituted; chiral alpha-amino acids; vibrational CD
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We synthesized by solution methods a water-soluble, terminally blocked heptapeptide based on five markedly helicogenic, C-alpha-tetrasubstituted alpha-amino acids C-alpha-methyl-L-norvalines and two strongly hydrophilic 2-amino-3-[1-(1,4,7-triazacyclononane)]-L-propanoic acid residues at positions 2 and 5. A Fourier transform infrared absorption and NMR analysis in deuterated chloroform and aqueous solutions of the heptapeptide and two side-chain protected synthetic precursors confirmed our working hypothesis that all oligomers are folded in the 3(10)-helical conformation. Based on these findings, we exploited this heptapeptide as a chiral reference compound for detailed electronic CD, vibrational CD, and Raman optical activity characterizations of the 3(10)-helix in aqueous solution. (C) 2004 Wiley Periodicals, Inc.
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