Journal
BIOCHEMICAL JOURNAL
Volume 382, Issue -, Pages 411-416Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20031481
Keywords
cardiomyocyte; CDC2; cell cycle; cell division; cyclin B
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Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might reinitiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.
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