Journal
GENE THERAPY
Volume 11, Issue 18, Pages 1363-1369Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gt.3302337
Keywords
plasmid DNA; gene transfer; ultrasound; hydrodynamic; vascular; skeletal muscle
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Over the last 5 years, physical methods of plasmid delivery have revolutionized the efficiency of nonviral gene transfer, in some cases reaching the efficiencies of viral vectors. In vivo electroporation dramatically increases transfection efficiency for a variety of tissues. Other methods with clinical precedent, pressure-perfusion and ultrasound, also improve plasmid gene transfer. Alternatives such as focused laser, magnetic fields and ballistic ( gene gun) approaches can also enhance delivery. As plasmid DNA appears to be a safe gene vector system, it seems likely that plasmid with physically enhanced delivery will be used increasingly in clinical trials.
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