Journal
INFECTION AND IMMUNITY
Volume 72, Issue 9, Pages 5470-5474Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.9.5470-5474.2004
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Funding
- NHLBI NIH HHS [R01 HL064883, R01HL64883] Funding Source: Medline
- NIAID NIH HHS [R01 AI47997, R01 AI047997] Funding Source: Medline
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We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.
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