Journal
OPTICS LETTERS
Volume 29, Issue 17, Pages 2016-2018Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.29.002016
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Funding
- NIBIB NIH HHS [R21 EB004602, EB000243, R24 EB000243] Funding Source: Medline
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We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption. The method, spectra triangulation MCOCT, can effectively suppress contributions from spectrally dependent scatterings from the sample without a priori knowledge of the scattering properties. We demonstrate molecular imaging with this new MCOCT modality by mapping the distribution of indocyanine green, a FDA-approved infrared red dye, within a stage 54 Xenopus laevis. (C) 2004 Optical Society of America.
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