Journal
TRENDS IN GENETICS
Volume 20, Issue 9, Pages 403-407Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2004.07.006
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We used the yeast genome sequences of gene families, microarray profiles and regulatory motif data to test the current wisdom that there is a strong correlation between regulatory motif structure and gene expression profile. Our results suggest that duplicate genes tend to be co-expressed but the correlation between motif content and expression similarity is generally poor, only similar to2-3% of expression variation can be explained by the motif divergence. Our observations suggest that, in addition to the cis-regulatory motif structure in the upstream region of the gene, multiple trans-acting factors in the gene network can influence the pattern of gene expression significantly.
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